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6th Swine in Biomedical Research Conference Program

Day One: September 23, 2017

3:00 pm - 4:00 pm

Arrivals and Registration
Installation of Posters

4:00pm - 6:00 pmOPENING SESSION
4:00pm - 4:15 pm Welcoming Remarks
Randall S. Prather, University of Missouri, Columbia, MO, USA
4:15pm - 4:30 pm Summary of 2014 Conference
Jorge Piedrahita, North Carolina State University, Raleigh, NC, USA
4:30 pm - 5:00 pm Setting the Stage – Breaking New Frontiers: Perspectives from a Young Investigator
Bhanu Telugu, University of Maryland, College Park, MD, USA
5:00 pm - 5:30 pm Keynote Address – Biomedicine: Stem Cells and Organ Generation: In vitro and in vivo approaches
Juan Carlos Izpisua-Belmonte, Salk Institute, San Diego, CA, USA
5:30 pm - 6:00 pm Keynote Address – Agriculture: Genome Editing for Agricultural Applications
Jonathan Lightner
, Genus plc, De Forest, WI, USA
6:00pm - 8:00 pmOPENING  RECEPTION

Day Two: September 24, 2017

7:30 am - 8:30 amContinental Breakfast (Provided) and Poster Viewing
8:30 am - 12:00 noonSESSION 1 - Technological Advances in Genetic Engineering
Session Chairs:
Bruce Whitelaw, Roslin Institute, Midlothian, UK;
Kiho Lee, Virginia State University, Blacksburg, VA, USA
8:30 am - 9:00 am Engineered Nucleases (ZFNs/TALENs/CRISPR). The Changing Landscape in Generation of Swine Models
Bruce Whitelaw, Roslin Institute, Midlothian, UK
9:00 am - 9:30 am Building a Pig Genome from Ground Up
Sean Stevens
, Synthetic Genomics, La Jolla, CA, USA
09:30 am - 10:00 am Gene Editing of CD163 Protects Pigs from PRRSv Infectivity
Kristin Whitworth, University of Missouri, Columbia, MO, USA
10:00 am - 11:00 am

Coffee Break (Provided) and
Poster Session 1:

Genetic Engineering - Current Advances
Regenerative Medicine

11:00 am - 11:30 am Germline Transplantation in Pigs
Jon Oatley
, Washington State University, Pullman, WA, USA
11:30 am - 11:45 am

A Novel Mutation of MITF Gene Modeling Human Waardenburg Syndrome Type 2A and Can Be Corrected by CRISP/Cas9 in Pigs (ABSTRACT PRESENTATION)
Jian Guo Zhao, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

11:45 am - 12:00 noon

Apancreatic Pigs Cloned Using PDX-1 Disrupted Fibroblasts Created via TALEN-Mediated Mutagenesis (ABSTRACT PRESENTATION)
Xi-Jun Yin, Yanbian University, Yanji, China

12:00 pm - 1:30 pmLUNCH (provided) and Poster Viewing
1:30 pm - 3:30 pmSESSION 2 Regenerative Medicine
Session Chair:
Jorge Piedrahita, NC State University, Raleigh, NC, USA
1:30 pm - 2:00 pm An Update on Xenotransplantation Research
Eckhard Wolf
, LMU Gene Center, Munich, Germany
2:00 pm - 2:30 pm A Swine Model of RPE-injury Induced Retinal Degeneration Used to Test the Efficacy of a Human iPSC-RPE Transplant
Juan Amaral, National Eye Institute, NIH, Bethesda, MD, USA
2:30 pm - 3:00 pm Gene Edited Swine Models and Solutions for Regenerative Medicine
Dan Carlson, Recombinetics, St. Paul, MN, USA
3:00 pm - 3:30 pm Impact of Genetic Engineered Donor Pigs on the Outcome of Xenotransplantation
Mohammed Mohiuddin, NHLBI/NIH, Bethesda, MD, USA
3:30 pm - 4:00 pmCoffee Break
4:00 pm - 6:00 pmSESSION 3 Dual Purpose with Dual Benefit: Use of Swine in Agriculture and Biomedical Research
Session Chair:
Harry Dawson, BHNRC/USDA/ARS, Beltsville, MD, USA
4:00 pm - 4:30 pm New Insights into Pediatric Nutrition and GI Development Using Piglets
Doug Burrin, Baylor College of Medicine, Houston, TX, USA
4:30 pm - 5:00 pm Developmental Origins of Altered Stress Resilience: The Yin and Yang of Microglia Activation 
Rodney Johnson, University of Illinois, Urbana Champagne, IL, USA
5:00 pm - 5:30 pm Neuro-immune Mechanisms in Early Life Stress Induced Gastrointestinal Disease
Adam Moeser, Michigan State University, East Lansing, MI, USA
5:30 pm - 5:45 pm

The Ossabaw Pig Model to Study the Effect of Dietary Patterns on Atherosclerosis Development and Progression (ABSTRACT PRESENTATION)
Nirupama Matthan, Tufts University, Boston, MA, USA

5:45 pm - 6:00 pm The Potential of Commercial Pig Farms as a Source of Spontaneous Genetic Models for Biomedical Research (ABSTRACT PRESENTATION)
Alex Clop Centre for Research in Agricultural Genomics, Barcelona, Spain

Day Three: September 25, 2017

7:30 am - 8:30 amContinental Breakfast (Provided) and Poster Viewing
8:30 am - 12:00 noonSESSION 4: Employing Porcine Models for Improving Accuracy of Preclinical Research
Session Chairs:
Eckhard Wolf, LMU, Munich, Germany;
Randall S. Prather, University of Missouri, Columbia, MO, USA
8:30 am - 9:00 am The Ongoing Cancer Model (OCM): A Platform for Transitional, Translational and Transformative Advances in Cancer Research
Larry Schook, University of Illinois, Urbana-Champagne, IL, USA
9:00 am - 9:30 am Swine Models of Congenital Heart Disease for Basic and Translational Research
Anne Moon, Weis Center for Research, Danville, PA, USA
9:30 am - 10:00 am Translational Utility of Porcine Disease Models
Chris Rogers, Exemplar Genetics, Iowa City, IA, USA
10:00 am - 11:00 am

Coffee Break and
Poster Session 2:

Dual Purpose with Dual Benefit - use of swine in agriculture and biomedical research
Improving accuracy of preclinical research

11:00 am - 11:30 am Porcine Models of Neurobehavioral Genetic Disorders
Robert Nicholls, University of Pittsburgh, Pittsburgh, PA, USA
11:30 am - 11:45 PM Comparative Nutrigenomics Analysis of the Pig, Mouse and Human (ABSTRACT PRESENTATION)
Harry Dawson, BHNRC/USDA/ARS, Beltsville, MD, USA
11:45 PM - 12:00 Noon The Miniature Swine as a Model in Toxicology and Translational Medicine (ABSTRACT PRESENTATION)
Guy Bouchard, Sinclair Bio Resources, LLC, Auxvasse, MO, USA
12:00 pm - 1:00 pmWORKING LUNCH (provided)
Community Resources and Joint NIH and USDA Programs
Neelakanta (Ravi) Ravindranath, NICHHD/NIH, Bethesda, MD, USA
Mark Mirando, USDA National Institute of Food and Agriculture, Washington, DC, USA
Miguel Contreras, NIH, Bethesda, MD, USA
Matt Portnoy, NIH, Bethesda, MD, USA
1:00 pm - 1:15 pmClosing Remarks and Conference Summary

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